Article

Tissue- and ethnicity-independent hypervariable DNA methylation states show evidence of establishment in the early human embryo

2021-12-18

Abstract excerpt

We analysed DNA methylation data from 30 datasets comprising 3,474 individuals, 19 tissues and 8 ethnicities at CpGs covered by the Illumina450K array. We identified 4,143 hypervariable CpGs (“hvCpGs”) with methylation in the top 5% most variable sites across multiple tissues and ethnicities. hvCpG methylation was influenced but not determined by genetic variation, and was not linked to probe reliability, epigenet...

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Literature Corpus work: f6c44454-d5bd-52e3-966b-1d76de2682ba
DOI: 10.1101/2021.12.17.473110

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