Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional sQTLs regulating PTK2B exon 31 splicing uncover an RNA-dependent modulation of its kinase activity and cellular phenotype.

Cell communication and signaling : CCS - 2 Apr 2026

Kato Masahide, Isazawa Ayaka, Ohki Ai, Fujita Akari, Araki Makoto, Yanaizu Motoaki, Kino Yoshihiro

Abstract excerpt

BACKGROUND: Genome-wide association studies have shown that polymorphisms in PTK2B (Protein Tyrosine Kinase 2 Beta), encoding the calcium-sensitive tyrosine kinase PYK2 (Proline-rich tyrosine kinase 2), are associated with an increased risk of Alzheimer’s disease (AD). However, it remains unclear which genetic variants of PTK2B are functionally important. A recent transcriptome-wide association study has...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alternative Splicing
Share to Alzheimer Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Movement

Share to Focal Adhesion Kinase 2

Share to Phenotype

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 41928225
DOI: 10.1186/s12964-026-02835-x
PMCID: PMC13217868

Genes

PTK2B
PCBP1
PCBP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional sQTLs regulating PTK2B exon 31 splicing uncover an RNA-dependent modulation of its kinase activity and cellular phenotype.PMID 41928225Read ↗

An Alzheimer’s disease-associated common regulatory variant in a PTK2B intron alters microglial functionSemantic proximity Read ↗

Mapping PTBP splicing in human brain identifies targets for therapeutic splice switching including <i>SYNGAP1</i>Semantic proximity Read ↗

Genetics of PLCG2 expression and splicing relative to Alzheimer’s disease riskSemantic proximity Read ↗

Alternatively spliced isoforms reveal a novel type of PTB domain in CCM2 proteinSemantic proximity Read ↗

Alzheimer risk gene product Pyk2 suppresses tau phosphorylation and phenotypic effects of tauopathy.Semantic proximity Read ↗

Protective variant in PLCγ2 mitigates Alzheimer’s disease-associated pathologies via enhancing beneficial microglia functionsSemantic proximity Read ↗

Expanding the clinical spectrum of PPP3CA variants - alternative isoforms matter.Semantic proximity Read ↗

17q21.31 locus regulates Parkinson’s disease relevant pathways through <i>KANSL1</i> activitySemantic proximity Read ↗

Adaptors for disorders of the brain? The cancer signaling proteins NEDD9, CASS4, and PTK2B in Alzheimer’s diseaseSemantic proximity Read ↗

PLCG2 across human disease: genetic variants, signaling mechanisms, and clinical implications.Semantic proximity Read ↗

Parkinson's disease-related gene variants influence pre-mRNA splicing processes.Semantic proximity Read ↗

Homozygous mutation in the eukaryotic translation initiation factor 2alpha phosphatase gene, PPP1R15B, is associated with severe microcephaly, short stature and intellectual disability.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.