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Article

Current quantitative methodologies for preimplantation genetic testing frequently misclassify meiotic aneuploidies as mosaic

15 Feb 2025

Abstract excerpt

OBJECTIVE: To study the biological origin of chromosomal abnormalities in embryos reported as mosaic after next-generation sequencing (NGS)-based preimplantation genetic testing for aneuploidy (PGT-A) and to assess the accuracy of current NGS-based methods in distinguishing meiotic from mitotic errors. DESIGN: Retrospective cohort study utilizing single-nucleotide polymorphism genotyping and karyomapping to...

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PMID: 39961387
DOI: 10.1016/j.fertnstert.2025.02.018

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