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Article

Mosaic human preimplantation embryos and their developmental potential in a prospective, non-selection clinical trial

18 Nov 2021

Abstract excerpt

Chromosome imbalance (aneuploidy) is the major cause of pregnancy loss and congenital disorders in humans. Analyses of small biopsies from human embryos suggest that aneuploidy commonly originates during early divisions, resulting in mosaicism. However, the developmental potential of mosaic embryos remains unclear. We followed the distribution of aneuploid chromosomes across 73 unselected preimplantation embryos...

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Identifiers

PMID: 34798051
DOI: 10.1016/j.ajhg.2021.11.002

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