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Segmental aneuploidy in human embryos is frequently mosaic with evidence of meiotic origin: insights from trophectoderm and inner cell mass analyses.

Fertility and sterility - 1 Sept 2026

Al Hashimi Balsam, Macklon Nick, Ahuja Kamal, Linara-Demakakou Elena, Raikundalia Bhavna, SenGupta Sioban, Gordon Tony, Griffin Darren K

Abstract excerpt

OBJECTIVE: To study the parental origin, timing, and within-embryo distribution of unbalanced structural chromosomal abnormalities (segmental aneuploidy) in human blastocysts initially classified as nonmosaic by single trophectoderm biopsy (TE1) during clinical preimplantation genetic testing for aneuploidy (PGT-A). DESIGN: Retrospective cohort study. SUBJECTS: Human blastocysts donated for research after...

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Aneuploidy
Blastocyst
Meiosis
Mosaicism
Polymorphism, Single Nucleotide

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Preimplantation Diagnosis

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PMID: 42259484
DOI: 10.1016/j.fertnstert.2026.06.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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