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Human embryos harbor complex mosaicism with broad presence of aneuploid cells during early development

24 Sept 2024

Abstract excerpt

Pre-implantation genetic testing for aneuploidy (PGT-A) is used in approximately half of in vitro fertilization cycles. Given the limited understanding of the genetics of human embryos, the current use of PGT-A is based on biologically uncertain assumptions and unvalidated guidelines, leading to the possibility of disposing of embryos with pregnancy potential. We isolated and sequenced all single cells (1133)...

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PMID: 39313513
DOI: 10.1038/s41421-024-00719-3

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