Article

Complexoform-restricted covalent TRMT112 ligands that allosterically agonize METTL5

2025-05-25

Abstract excerpt

Adaptors serve as hubs to regulate diverse protein complexes in cells. This multitude of functions can complicate the study of adaptors, as their genetic disruption may simultaneously impair the activities of several compositionally distinct complexes (or adaptor ‘complexoforms’). Here we describe the chemical proteomic discovery of bicyclopyrrolidine acrylamide stereoprobes that react with cysteine-100 (C100) of...

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Literature Corpus work: 0d8b70a0-a5a8-58ba-b151-a2102ce8fd46
DOI: 10.1101/2025.05.25.655995

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