Article

A palmitoyl transferase chemical genetic system to map ZDHHC-specific <i>S</i> -acylation

2023-04-18

Abstract excerpt

The 23 human ZDHHC S -acyltransferases catalyze long-chain S -acylation at cysteine residues across an extensive network of hundreds of proteins important for normal physiology or dysregulated in disease. Here we present a technology platform to directly map the protein substrates of a specific ZDHHC for the first time at the whole proteome level, in intact cells. Structure-guided engineering of paired ZDHHC ‘ho...

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Literature Corpus work: 6da97d5d-c150-581a-a6e0-d55e919c0d2e
DOI: 10.1101/2023.04.18.537386

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