PCMT1 generates the C-terminal cyclic imide degron on CRBN substrates

Abstract excerpt

The E3 ligase substrate adapter cereblon (CRBN), the primary target of clinical agents thalidomide and lenalidomide, recognizes endogenous substrates bearing the C-terminal cyclic imide modification. Although C-terminal cyclic imides can form spontaneously, an enzyme that regulates the formation of these modifications and thereby promotes a biological pathway connecting substrates to CRBN is unknown. Here, we repo...

Topics

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• Cloning, Molecular
• DNA, Complementary
• Gene Expression Regulation, Enzymologic
• Gene Order
• Open Reading Frames
• Peptidase Inhibition and Analysis
• Protein Degradation and Inhibitors
• Protein Structure, Tertiary

Identifiers and source

Literature Corpus work

75fc5258-14ea-5848-8290-f3c27378acf4

DOI

10.1101/2025.03.24.645050