Article

TTLL4 glutamyltransferase is a therapeutic target for NPM1-mutated acute myeloid leukemia

2025-04-09

Abstract excerpt

NPM1-mutated acute myeloid leukemia (AML) is defined by aberrant cytoplasmic localization of the mutant NPM1c protein, and therapeutic strategies targeting this specific disease remain limited. Here, we identify TTLL4, a mono-glutamate glutamyltransferase, as a selective vulnerability in NPM1c AML. TTLL4 catalyzes post-translational hyper-glutamylation of NPM1c at E126, stabilizes its cytoplasmic localization and...

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Literature Corpus work: 8b6115f5-7a11-5b0f-9b49-20f637a6d0ca
DOI: 10.1101/2025.04.07.647605

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