Article

Probing pathophysiology of extracellular cGAMP with substrate-selective ENPP1

2021-05-04

Abstract excerpt

The biology of the immune second messenger cGAMP depends on its cellular localization. cGAMP, which is synthesized in response to cytosolic double-stranded DNA, also exists in the extracellular space as a paracrine immunotransmitter that enhances the anticancer immune response. However, the role of extracellular cGAMP is unexplored outside of cancer due to a lack of tools to systemically manipulate it. The extrace...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a97ae399-5edf-5d5e-a109-88f6f8fd4631
DOI: 10.1101/2021.05.04.442665

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Probing pathophysiology of extracellular cGAMP with substrate-selective ENPP1DOI 10.1101/2021.05.04.442665Read

ENPP1 buffers extracellular cGAMP in brown adipose tissue to limit insulin resistanceSemantic proximity Read

Cleavage of the catalytic intermediate fine-tunes cGAS signallingSemantic proximity Read

cGAMP the travelling messengerSemantic proximity Read

Regulation of cGAS‐Mediated Immune Responses and ImmunotherapySemantic proximity Read

ABCC1/MRP1 exports cGAMP and modulates cGAS-dependent immunitySemantic proximity Read

Cell autonomous inflammation in VEXAS is mediated by cGAS-STINGSemantic proximity Read

PCMT1 generates the C-terminal cyclic imide degron on CRBN substratesSemantic proximity Read

Glutamate Carboxypeptidase II: An Overview of Structural Studies and Their Importance for Structure-Based Drug Design and Deciphering the Reaction Mechanism of the EnzymeSemantic proximity Read

Cytosolic Peptide: N-Glycanase (NGLY1)-from Basic Biology to Genetic Disorder, NGLY1 Deficiency.Semantic proximity Read

SLC19A1 is an importer of the immunotransmitter cGAMPSemantic proximity Read

Evolutionary origin, cyclic peptide targeting and physiological activation of Peptidyl Arginine Deiminase 4Semantic proximity Read

Insights into the complexities of Citrullination: From immune regulation to autoimmune diseaseSemantic proximity Read