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CRBN‐PROTACs in Cancer Therapy: From Mechanistic Insights to Clinical Applications

1 Nov 2024

Abstract excerpt

Cereblon (CRBN), a member of the E3 ubiquitin ligase complex, has gained significant attention as a therapeutic target in cancer. CRBN regulates the degradation of various proteins in cancer progression, including transcription factors and signaling molecules. PROTACs (proteolysis-targeting chimeras) are a novel approach that uses the cell's degradation system to remove disease-causing proteins selectively....

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PMID: 39496477
DOI: 10.1111/cbdd.70009

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