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Citrullination and the protein code: crosstalk between post-translational modifications in cancer

1 Oct 2023

Abstract excerpt

Post-translational modifications (PTMs) of proteins are central to epigenetic regulation and cellular signalling, playing an important role in the pathogenesis and progression of numerous diseases. Growing evidence indicates that protein arginine citrullination, catalysed by peptidylarginine deiminases (PADs), is involved in many aspects of molecular and cell biology and is emerging as a potential druggable...

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PMID: 37778382
DOI: 10.1098/rstb.2022.0243

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