Article

Engineering CRBN for rapid identification of next generation binders

2024-01-20

Abstract excerpt

The majority of clinical degrader candidates utilize an immunomodulatory imide drug (IMiD)-based derivative, that directs their target substrate to the E3 ligase receptor Cereblon (CRBN), however, concomitant neo-substrate degradation by IMiDs often results in severe off-target effects. Further biophysical screening is needed to discover CRBN binders that might overcome these safety concerns, but the previously re...

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Literature Corpus work: 7b181240-1168-57e0-9785-8496c4fea8b2
DOI: 10.1101/2024.01.18.576231

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