Article

On-target toxicity of GSPT1 molecular glue degraders in mice

2026-02-16

Abstract excerpt

<h4>Summary</h4> Thalidomide is teratogenic in humans but not in rodents due to species-specific differences in the sequence of Cereblon (CRBN), an E3 ubiquitin ligase targeted by thalidomide and its derivative molecular glue degraders (MGDs). This species divergence has hindered the accurate prediction of MGD-induced toxicities in standard laboratory animals. GSPT1 MGDs, such as CC-90009, have shown potent antic...

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Literature Corpus work: c84619e7-75b2-52a3-901a-72396110c70b
DOI: 10.64898/2026.02.14.705470

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