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Article

Walking to protect against cognitive decline: the role of APOE genotype and sex.

Biology of sex differences - 21 Feb 2026

Burma Joel S, Rosano Caterina, Best John R, Simonsick Eleanor M, Liu-Ambrose Teresa, Barha Cindy K

Abstract excerpt

BACKGROUND: The apolipoprotein E (APOE) ε4 allele is a risk factor for late-onset Alzheimer's disease; however, risk varies by sex and lifestyle. Regular physical activity is known to mitigate cognitive decline; whether the degree of benefit differs by APOE genotype, sex, and race remains unknown. METHODS: Analyses utilized data from 2,985 participants in the Health, Aging, and Body Composition (HABC) cohort,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41723502
DOI: 10.1186/s13293-026-00860-6
PMCID: PMC13032221

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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