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Article

Mendelian randomization identifies blood metabolites previously linked to midlife cognition as causal candidates in Alzheimer's disease.

Proceedings of the National Academy of Sciences of the United States of America - 20 Apr 2021

Lord Jodie, Jermy Bradley, Green Rebecca, Wong Andrew, Xu Jin, Legido-Quigley Cristina, Dobson Richard, Richards Marcus, Proitsi Petroula

Abstract excerpt

There are currently no disease-modifying treatments for Alzheimer's disease (AD), and an understanding of preclinical causal biomarkers to help target disease pathogenesis in the earliest phases remains elusive. Here, we investigated whether 19 metabolites previously associated with midlife cognition-a preclinical predictor of AD-translate to later clinical risk, using Mendelian randomization (MR) to tease out...

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Blood
Causality
Cholesterol
Cholesterol, HDL
Cholesterol, LDL

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33879569
DOI: 10.1073/pnas.2009808118
PMCID: PMC8072203

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