Article

Biliverdin Reductase A is a major determinant of neuroprotective Nrf2 signaling

2025-06-08

Abstract excerpt

Biliverdin reductase A (BVRA), the terminal enzyme in heme catabolism, generates the neuroprotective and lipophilic antioxidant bilirubin. Here, we identify a novel non-enzymatic role for BVRA in redox regulation. We show that BVRA directly interacts with nuclear factor erythroid-derived factor-like 2 (Nrf2), the master regulator of redox homeostasis, to modulate target signaling pathways. ChIP-seq and RNA-seq ana...

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Identifiers and source

Literature Corpus work: 66e33639-e850-534a-a05f-4b53e4532383
DOI: 10.1101/2025.06.04.657936

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