Article

Role of the Nrf2/ARE downregulation and mtDNA damage in the cognitive impairments in APP/PS1 mice

2023-04-13

Abstract excerpt

<title>Abstract</title> <p>Mitochondrial dysfunction is one of the key events in the pathogenesis of Alzheimer's disease (AD) that mediates cognitive impairment. In this study, we examined the extent to which the mitochondrial DNA (mtDNA) of APP/PS1 mouse strain is susceptible to damage accumulation and explored the potential relationship between mtDNA integrity and other physiological processes. The gut microbio...

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Literature Corpus work: fb869f1d-877d-550d-a23d-c98951ad057b
DOI: 10.21203/rs.3.rs-2738450/v1

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