Article

The unfolded protein response transcription factor XBP1s ameliorates Alzheimer’s disease by improving synaptic function and proteostasis

2022-06-23

Abstract excerpt

Alteration in the buffering capacity of the proteostasis network is an emerging feature of Alzheimer’s disease (AD), highlighting the occurrence of endoplasmic reticulum (ER) stress. The unfolded protein response (UPR) is the main adaptive pathway to cope with protein folding stress at the ER. Inositol requiring enzyme-1 (IRE1) is an ER-located kinase and endoribonuclease that operates as a central ER stress senso...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: a828b6d9-4ff9-5cfd-b498-40bad4cbef3b
DOI: 10.1101/2022.06.21.496869

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The unfolded protein response transcription factor XBP1s ameliorates Alzheimer’s disease by improving synaptic function and proteostasisDOI 10.1101/2022.06.21.496869Read

Control of mammalian brain ageing by the unfolded protein response transcription factor XBP1Semantic proximity Read

Optimized AAV to express the unfolded protein response transcription factor XBP1s ameliorates Alzheimer’s disease features in mouse modelsSemantic proximity Read

Unfolded protein response IRE1/XBP1 signaling is required for healthy mammalian brain agingSemantic proximity Read

XBP-1 deficiency in the nervous system reveals a homeostatic switch to activate autophagySemantic proximity Read

Regulation of Memory Formation by the Transcription Factor XBP1Semantic proximity Read

Early and late chaperone intervention therapy boosts XBP1s and ADAM10, restores proteostasis, and rescues learning in Alzheimer’s Disease miceSemantic proximity Read

Induction of the Endoplasmic-Reticulum-Stress Response: MicroRNA-34a Targeting of the IRE1α-BranchSemantic proximity Read

Amyotrophic lateral sclerosis (ALS) and Alzheimer’s disease (AD) are characterised by differential activation of ER stress pathways: focus on UPR target genesSemantic proximity Read

IRE1 signaling exacerbates Alzheimer’s disease pathogenesisSemantic proximity Read

Constitutive XBP-1s-mediated activation of the endoplasmic reticulum unfolded protein response protects against pathological tau.Semantic proximity Read

Enforced dimerization between XBP1s and ATF6f enhances the protective effects of the UPR in models of neurodegeneration.Semantic proximity Read

C/ EBPβ : A transcription factor associated with the irreversible progression of Alzheimer's diseaseSemantic proximity Read