Article

MiR-7a-Klf4 axis as a regulator and therapeutic target of neuroinflammation and ferroptosis in Alzheimer’s disease

2025-03-25

Abstract excerpt

<h4>ABSTRACT</h4> Neuroinflammation and ferroptosis significantly contribute to neuronal death in Alzheimer’s disease (AD) and other neurodegenerative disorders. MicroRNAs (miRNAs) are crucial regulators of these pathological processes. We employed transcriptomic analysis in an APP/PSEN1 Tg AD mouse model to identify dysregulated miRNAs and construct a miRNA-mRNA-pathway network. We discovered increased miR7a exp...

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Literature Corpus work: 5f5a21cb-e9ae-5712-948b-12197151f966
DOI: 10.1101/2025.03.24.644978

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