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DNA repair factor BRCA1 depletion occurs in Alzheimer brains and impairs cognitive function in mice

30 Nov 2015

Abstract excerpt

Maintaining DNA integrity is vital for all cells and organisms. Defective DNA repair may contribute to neurological disorders, including Alzheimer's disease (AD). We found reduced levels of BRCA1, but not of other DNA repair factors, in the brains of AD patients and human amyloid precursor protein (hAPP) transgenic mice. Amyloid-β oligomers reduced BRCA1 levels in primary neuronal cultures. In wild-type mice,...

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PMID: 26615780
DOI: 10.1038/ncomms9897

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