Article

DNA Break-Induced Epigenetic Alterations Promote Plaque Formation and Behavioral Deficits in an Alzheimer’s Disease Mouse Model

2025-10-22

Abstract excerpt

The dramatic increase in human longevity over recent decades has contributed to a rising prevalence of age-related diseases, including neurodegenerative disorders such as Alzheimer’s disease (AD). While accumulating evidence implicates DNA damage and epigenetic alterations in the pathogenesis of AD, their precise mechanistic role remains unclear. To address this, we developed a novel mouse model, DICE (Dementia fr...

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Literature Corpus work: 4b8dc6b7-6f0a-52be-829d-1d2b2e3e394a
DOI: 10.1101/2025.10.21.683739

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