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Article

Enhanced Ca(2+)-dependent glutamate release from astrocytes of the BACHD Huntington's disease mouse model.

Neurobiology of disease - 1 Oct 2013

Lee William, Reyes Reno C, Gottipati Manoj K, Lewis Karon, Lesort Mathieu, Parpura Vladimir, Gray Michelle

Abstract excerpt

Huntington's disease (HD) causes preferential loss of a subset of neurons in the brain although the huntingtin protein is expressed broadly in various neural cell types, including astrocytes. Glutamate-mediated excitotoxicity is thought to cause selective neuronal injury, and brain astrocytes hav...

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Identifiers

PMID: 23756199
DOI: 10.1016/j.nbd.2013.06.002
PMCID: PMC3748209

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23756199-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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