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Application of CRISPR genetic screens to investigate neurological diseases

14 Nov 2019

Abstract excerpt

The adoption of CRISPR-Cas9 technology for functional genetic screens has been a transformative advance. Due to its modular nature, this technology can be customized to address a myriad of questions. To date, pooled, genome-scale studies have uncovered genes responsible for survival, proliferation, drug resistance, viral susceptibility, and many other functions. The technology has even been applied to the...

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PMID: 31727120
DOI: 10.1186/s13024-019-0343-3

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