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<i>In vivo</i> BMAL1 occupancy mapping using MACS-Calling Cards reveals disease-associated retargeting in <i> Cln3 <sup>Δex7/8</sup> </i> astrocytes

2026-05-05

Abstract excerpt

<h4>ABSTRACT</h4> Astrocytic homeostatic programs, many of which are regulated by the circadian clock, are disrupted early in neurodegenerative disease. The core clock transcription factor (TF) BMAL1 is required for normal astrocyte function, but its role during disease remains unclear. This is partly because methods for identifying cell type-specific TF binding sites are limited. Here, we developed MACS-Calling...

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Literature Corpus work
75951ab9-3925-52aa-9643-21a1a3c1c12d
DOI
10.64898/2026.04.30.721783
Open publication

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<i>In vivo</i> BMAL1 occupancy mapping using MACS-Calling Cards reveals disease-associated retargeting in <i> Cln3 <sup>Δex7/8</sup> </i> astrocytesDOI 10.64898/2026.04.30.721783
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