Article

ZBTB7A regulates MDD-specific chromatin signatures and astrocyte-mediated stress vulnerability in orbitofrontal cortex

2023-05-04

Abstract excerpt

<h4>Summary</h4> Hyperexcitability in the orbitofrontal cortex (OFC) is a key clinical feature of anhedonic domains of Major Depressive Disorder (MDD). However, the cellular and molecular substrates underlying this dysfunction remain unknown. Here, cell-population-specific chromatin accessibility profiling in human OFC unexpectedly mapped genetic risk for MDD exclusively to non-neuronal cells, and transcriptomic...

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Literature Corpus work: 9ee09ce3-0876-5149-8a74-ad8a52071ded
DOI: 10.1101/2023.05.04.539425

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