Article

Principles of dengue virus evolvability derived from genotype-fitness maps in human and mosquito cells

2020-02-07

Abstract excerpt

<h4>ABSTRACT</h4> Dengue virus (DENV), an arbovirus infecting over 100 million annually, cycles between human and mosquito hosts 1 . Examining how DENV adapts to such different host environments could uncover principles of arbovirus transmission and emergence. Here we combine sequential passaging and ultra-deep sequencing to examine the sequence dynamics and fitness changes of DENV populations adapting to human...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 757e8d7a-cee0-5ae5-8c93-b4de1bb59b9b
DOI: 10.1101/2020.02.05.936195

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Principles of dengue virus evolvability derived from genotype-fitness maps in human and mosquito cellsDOI 10.1101/2020.02.05.936195Read

Principles of dengue virus evolvability derived from genotype-fitness maps in human and mosquito cells.Semantic proximity Read

Getting to Know Viral Evolutionary Strategies: Towards the Next Generation of Quasispecies Models.Semantic proximity Read

Intrahost Genetic Diversity of Dengue Virus in Human Hosts and Mosquito Vectors under Natural Conditions Which Impact Replicative Fitness In Vitro.Semantic proximity Read

Adaptive Evolution of Dengue Virus: Interplay Between Viral Genetics and Host Immunity.Semantic proximity Read

Adaptive Evolution as a Driving Force of the Emergence and Re-Emergence of Mosquito-Borne Viral DiseasesSemantic proximity Read

Group Selection and Contribution of Minority Variants during Virus Adaptation Determines Virus Fitness and Phenotype.Semantic proximity Read

Tracking Dengue Virus Intra-host Genetic Diversity during Human-to-Mosquito Transmission.Semantic proximity Read

Mutational and fitness landscapes of an RNA virus revealed through population sequencing.Semantic proximity Read

Dengue virus genomic variation associated with mosquito adaptation defines the pattern of viral non-coding RNAs and fitness in human cells.Semantic proximity Read

Genetic Drift, Purifying Selection and Vector Genotype Shape Dengue Virus Intra-host Genetic Diversity in Mosquitoes.Semantic proximity Read

Viral quasispecies.Semantic proximity Read

Estimating Fitness of Viral Quasispecies from Next-Generation Sequencing Data.Semantic proximity Read