Article
Tradeoffs between proliferation and transmission in virus evolution- insights from evolutionary and functional analyses of SARS-CoV-2.
Virology journal - 19 Apr 2025
Tai Jui-Hung, Lee Ding-Chin, Lin Hsin-Fu, Chao Tai-Ling, Ruan Yongsen, Cheng Ya-Wen, Chou Yu-Chi, Lin You-Yu, Chang Sui-Yuan, Chen Pei-Jer, Yeh Shiou-Hwei, Wang Hurng-Yi
Abstract excerpt
To be successful, a virus must maintain high between-host transmissibility while also effectively adapting within hosts. The impact of these potentially conflicting demands on viral genetic diversity and adaptation remains largely unexplored. These modes of adaptation can induce uncorrelated selection, bring mutations that enhance certain fitness aspects at the expense of others to high freqency, and contribute...
Read the complete abstract on PubMedTopics
- SARS-CoV-2
- COVID-19
- Humans
- Evolution, Molecular
- Mutation
- Spike Glycoprotein, Coronavirus