Article
Genetic Drift, Purifying Selection and Vector Genotype Shape Dengue Virus Intra-host Genetic Diversity in Mosquitoes.
PLoS genetics - 1 Jun 2016
Lequime Sebastian, Fontaine Albin, Ar Gouilh Meriadeg, Moltini-Conclois Isabelle, Lambrechts Louis
Abstract excerpt
Due to their error-prone replication, RNA viruses typically exist as a diverse population of closely related genomes, which is considered critical for their fitness and adaptive potential. Intra-host demographic fluctuations that stochastically reduce the effective size of viral populations are a challenge to maintaining genetic diversity during systemic host infection. Arthropod-borne viruses (arboviruses)...
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