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Article

Principles of dengue virus evolvability derived from genotype-fitness maps in human and mosquito cells.

eLife - 25 Jan 2021

Dolan Patrick T, Taguwa Shuhei, Rangel Mauricio Aguilar, Acevedo Ashley, Hagai Tzachi, Andino Raul, Frydman Judith

Abstract excerpt

Dengue virus (DENV) cycles between mosquito and mammalian hosts. To examine how DENV populations adapt to these different host environments, we used serial passage in human and mosquito cell lines and estimated fitness effects for all single-nucleotide variants in these populations using ultra-deep sequencing. This allowed us to determine the contributions of beneficial and deleterious mutations to the collective...

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Identifiers

PMID: 33491648
DOI: 10.7554/eLife.61921
PMCID: PMC7880689

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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