Article
Group Selection and Contribution of Minority Variants during Virus Adaptation Determines Virus Fitness and Phenotype.
PLoS pathogens - 1 May 2015
Bordería Antonio V, Isakov Ofer, Moratorio Gonzalo, Henningsson Rasmus, Agüera-González Sonia, Organtini Lindsey, Gnädig Nina F, Blanc Hervé, Alcover Andrés, Hafenstein Susan, Fontes Magnus, Shomron Noam, Vignuzzi Marco
Abstract excerpt
Understanding how a pathogen colonizes and adapts to a new host environment is a primary aim in studying emerging infectious diseases. Adaptive mutations arise among the thousands of variants generated during RNA virus infection, and identifying these variants will shed light onto how changes in tropism and species jumps can occur. Here, we adapted Coxsackie virus B3 to a highly permissive and less permissive...
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