Article

I helix Mediates the Allosteric Regulation in Cytochrome P450cam

2025-02-07

Abstract excerpt

Cytochrome P450cam, a key monooxygenase in the P450 superfamily, is pivotal in metabolic and industrial processes. Despite extensive studies, a unified mechanism governing its conformational heterogeneity, substrate-dependent allostery, and multi-substrate binding remains elusive. Here, integrating molecular dynamics simulations, NMR pseudocontact shift (PCS) analysis, and crystallographic data, we identify the I-...

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Literature Corpus work: 75766fc2-53a2-52e4-83eb-653833e2ca0d
DOI: 10.1101/2025.02.06.636992

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