Article

Rescue of Conformational Dynamics in Enzyme Catalysis by Directed Evolution

2017-09-05

Abstract excerpt

Rational design and directed evolution have proved to be successful approaches to increase catalytic efficiencies of both natural and artificial enzymes 1-3 . However, a comprehensive understanding of how evolution shapes the energy landscape of catalysis remains a fundamental challenge. Protein dynamics is widely recognized as important, but due to the inherent flexibility of biological macromolecules it is ofte...

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Literature Corpus work: b0eada06-047d-572c-8cca-584a287a9f73
DOI: 10.1101/185009

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