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Article

Conformational Heterogeneity and the Affinity of Substrate Molecular Recognition by Cytochrome P450cam.

Biochemistry - 27 Jun 2017

Basom Edward J, Manifold Bryce A, Thielges Megan C

Abstract excerpt

The broad and variable substrate specificity of cytochrome P450 enzymes makes them a model system for studying the determinants of protein molecular recognition. The archetypal cytochrome P450cam (P450cam) is a relatively specific P450, a feature once attributed to the high rigidity of its active site. However, increasingly studies have provided evidence of the importance of conformational changes to P450cam...

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Identifiers

PMID: 28581729
DOI: 10.1021/acs.biochem.7b00238
PMCID: PMC5816979

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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