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Article

Rescue of conformational dynamics in enzyme catalysis by directed evolution.

Nature communications - 3 Apr 2018

Otten Renee, Liu Lin, Kenner Lillian R, Clarkson Michael W, Mavor David, Tawfik Dan S, Kern Dorothee, Fraser James S

Abstract excerpt

Rational design and directed evolution have proved to be successful approaches to increase catalytic efficiencies of both natural and artificial enzymes. Protein dynamics is recognized as important, but due to the inherent flexibility of biological macromolecules it is often difficult to distinguish which conformational changes are directly related to function. Here, we use directed evolution on an impaired...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 29615624
DOI: 10.1038/s41467-018-03562-9
PMCID: PMC5883053

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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