Article

Widespread impact of immunoglobulin V gene allelic polymorphisms on antibody reactivity

2023-06-07

Abstract excerpt

<h4>ABSTRACT</h4> The ability of human immune system to generate antibodies to any given antigen can be strongly influenced by immunoglobulin V gene (IGV) allelic polymorphisms. However, previous studies have provided only a limited number of examples. Therefore, the prevalence of this phenomenon has been unclear. By analyzing >1,000 publicly available antibody-antigen structures, we show that many IGV allelic po...

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Literature Corpus work: 7571e27f-2fab-5a96-93ad-5c2bdf0ca3c2
DOI: 10.1101/2023.06.06.543969

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