Article

Defining neutralization and allostery by antibodies against COVID-19 variants

2023-01-23

Abstract excerpt

<title>Abstract</title> <p>The changing landscape of mutations in the SARS-CoV-2 Spike protein is linked to the emergence of variants, immune-escape and reduced efficacy of the existing repertoire of anti-viral antibodies. A major factor that contributes to the functional activity of the neutralizing antibodies are the intrinsic quaternary changes that occur as a result of antibody-Spike trimer interactions. In t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e71d6d2c-2e26-566b-b356-b68bfc8e57e9
DOI: 10.21203/rs.3.rs-2465199/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Defining neutralization and allostery by antibodies against COVID-19 variantsDOI 10.21203/rs.3.rs-2465199/v1Read

Defining neutralization and allostery by antibodies against COVID-19 variantsSemantic proximity Read

Mapping the allosteric effects that define functional activity of SARS-CoV-2 specific antibodiesSemantic proximity Read

A High-Resolution Approach to Mapping Spike Protein Evolution for Advancing Antibody Therapy DesignSemantic proximity Read

Altered spike dynamics drives immune evasion of SARS-CoV-2Semantic proximity Read

Dynamic mutational profiling of binding interactions and allosteric networks in conformational ensembles of the SARS-CoV-2 spike protein complexes with classes of antibodies targeting cryptic binding sites: confluence of binding and allostery determines molecular mechanisms and hotspots of immune escapeSemantic proximity Read

Landscape of human antibody recognition of the SARS-CoV-2 receptor binding domainSemantic proximity Read

Quantitative Characterization and Prediction of the Binding Determinants and Immune Escape Hotspots for Groups of Broadly Neutralizing Antibodies Against Omicron Variants: Atomistic Modeling of the SARS-CoV-2 Spike Complexes with Antibodies.Semantic proximity Read

Defining the Antigenic Topology and Prospective Binding Breadth of Vaccination-induced SARS-CoV-2 Neutralizing AntibodiesSemantic proximity Read

Key substitutions in the spike protein of SARS-CoV-2 variants can predict resistance to monoclonal antibodies, but other substitutions can modify the effectsSemantic proximity Read

Structural basis of Omicron immune evasion: A comparative computational study of Spike protein-Antibody interactionSemantic proximity Read

Integrative Computational Modeling of Distinct Binding Mechanisms for Broadly Neutralizing Antibodies Targeting SARS-CoV-2 Spike Omicron Variants: Balance of Evolutionary and Dynamic Adaptability in Shaping Molecular Determinants of Immune EscapeSemantic proximity Read

Defining variant-resistant epitopes targeted by SARS-CoV-2 antibodies: A global consortium studySemantic proximity Read