Article

Systems-Scale Structural Modeling Reveals the Germline Architecture of Immunodominance

2026-06-04

Abstract excerpt

<h4>Summary</h4> The adaptive immune system generates diverse antibodies to protect against infection, yet responses often focus on a limited number of antigenic sites, a phenomenon called immunodominance. Using the SARS-CoV-2 receptor-binding domain as a model, this study combines large-scale antibody sequencing, deep mutational scanning, and AlphaFold 3 structural modeling to investigate the basis of immunodomi...

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Literature Corpus work: 5f704b03-652d-53c6-8a88-d7a4b2a3d747
DOI: 10.64898/2026.06.02.729678

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