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Article

An allelic atlas of immunoglobulin heavy chain variable regions reveals antibody binding epitope preference resilient to SARS-CoV-2 mutation escape.

Frontiers in immunology - 1 Jan 2024

Deng Weiqi, Niu Xuefeng, He Ping, Yan Qihong, Liang Huan, Wang Yongping, Ning Lishan, Lin Zihan, Zhang Yudi, Zhao Xinwei, Feng Liqiang, Qu Linbing, Chen Ling

Abstract excerpt

Background: Although immunoglobulin (Ig) alleles play a pivotal role in the antibody response to pathogens, research to understand their role in the humoral immune response is still limited. Methods: We retrieved the germline sequences for the IGHV from the IMGT database to illustrate the amino acid polymorphism present within germline sequences of IGHV genes. We aassembled the sequences of IgM and IgD repertoire...

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Share to Antibodies, Neutralizing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Immune Evasion

Share to Immunoglobulin Heavy Chains

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Share to Spike Glycoprotein, Coronavirus

Source

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Identifiers

PMID: 39840032
DOI: 10.3389/fimmu.2024.1471396
PMCID: PMC11746035

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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