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Article

One thousand SARS-CoV-2 antibody structures reveal convergent binding and near-universal immune escape.

Cell systems - 21 Jan 2026

Feng Zirui, Sang Zhe, Xiang Yufei, Escalera Alba, Weshler Adi, Schneidman-Duhovny Dina, García-Sastre Adolfo, Shi Yi

Abstract excerpt

Understanding antibody recognition and adaptation to viral evolution is central to vaccine and therapeutic development. Over 1,100 SARS-CoV-2 antibody structures have been resolved, marking the largest structural biology effort for a single pathogen. We present a comprehensive analysis of this landmark dataset to investigate the principles of antibody recognition and immune escape. Human immunoglobulins and...

Read the complete abstract on PubMed

Topics

SARS-CoV-2
Humans
Antibodies, Viral
Immune Evasion
COVID-19
Spike Glycoprotein, Coronavirus

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Epitopes

Antibodies, Neutralizing

Mutation

Single-Chain Antibodies

Source

Identifiers

PMID: 41274284
DOI: 10.1016/j.cels.2025.101452

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 18 Oct 2026.

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