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Article

Widespread impact of immunoglobulin V-gene allelic polymorphisms on antibody reactivity

30 Sept 2023

Abstract excerpt

The ability of the human immune system to generate antibodies to any given antigen can be strongly influenced by immunoglobulin V-gene allelic polymorphisms. However, previous studies have provided only limited examples. Therefore, the prevalence of this phenomenon has been unclear. By analyzing >1,000 publicly available antibody-antigen structures, we show that many V-gene allelic polymorphisms in antibody...

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PMID: 37777966
DOI: 10.1016/j.celrep.2023.113194

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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