Article

Mapping affinity and allostery in human IgG antibody Fc region-Fc γ receptor interactions

2025-04-01

Abstract excerpt

<h4>ABSTRACT</h4> IgG antibodies, required for a functional immune system, recognize antigens and neutralize pathogens using their Fab regions, while signaling to the immune system by binding to host Fc γ receptors (FcγRs) through their Fc regions. These FcγR interactions initiate and modulate antibody-mediated effector functions that are essential for host immunity, therapeutic monoclonal antibody effectiveness...

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Literature Corpus work: 88faaab9-5998-5edd-b243-35b05484dba2
DOI: 10.1101/2025.03.28.645945

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