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Constructing genotype and phenotype network helps reveal disease heritability and phenome-wide association studies.

BMC genomics - 12 Dec 2025

Cao Xuewei, Zhu Lirong, Liang Xiaoyu, Zhang Shuanglin, Sha Qiuying

Abstract excerpt

BACKGROUND: Analyses of a bipartite Genotype and Phenotype Network (GPN), linking the genetic variants and phenotypes based on statistical associations, provide an integrative approach to elucidate the complexities of genetic relationships across diseases and identify pleiotropic loci. In this study, we assess contributions to constructing a well-defined GPN with a clear representation of genetic associations by...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 41382283
DOI: 10.1186/s12864-025-12239-9
PMCID: PMC12817677

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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