Article

Constructing genotype and phenotype network helps reveal disease heritability and phenome-wide association studies

2023-11-20

Abstract excerpt

Analyses of a bipartite Genotype and Phenotype Network (GPN), linking the genetic variants and phenotypes based on statistical associations, provide an integrative approach to elucidate the complexities of genetic relationships across diseases and identify pleiotropic loci. In this study, we first assess contributions to constructing a well-defined GPN with a clear representation of genetic associations by compari...

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Literature Corpus work: 6747f51f-6b67-5dcf-b2cc-5cb16a6883ea
DOI: 10.1101/2023.11.14.23297400

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