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Article

Estimation of a genetic Gaussian network using GWAS summary data.

Biometrics - 3 Oct 2024

Yang Yihe, Lorincz-Comi Noah, Zhu Xiaofeng

Abstract excerpt

A genetic Gaussian network of multiple phenotypes, constructed through the inverse matrix of the genetic correlation matrix, is informative for understanding the biological dependencies of the phenotypes. However, its estimation may be challenging because the genetic correlation estimates are biased due to estimation errors and idiosyncratic pleiotropy inherent in GWAS summary statistics. Here, we introduce a...

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PMID: 39656744
DOI: 10.1093/biomtc/ujae148
PMCID: PMC11639901

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