Article

Differential activity and expression of human 5β-reductase (AKR1D1) splice variants

2020-06-10

Abstract excerpt

Steroid hormones, including glucocorticoids and androgens, exert a wide variety of effects in the body across almost all tissues. The steroid A-ring 5β-reductase (AKR1D1) is expressed in human liver and testes, and three splice variants have been identified ( AKR1D1-001, AKR1D1-002, AKR1D1-006 ). Amongst these, AKR1D1-002 is the best described; it modulates steroid hormone availability and catalyses an important...

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Literature Corpus work: 7504d479-92f7-5222-93ed-0552b6aa7f36
DOI: 10.1101/2020.06.09.142539

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