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Article

5α-Reductase Type 2 Regulates Glucocorticoid Action and Metabolic Phenotype in Human Hepatocytes.

Endocrinology - 1 Aug 2015

Nasiri Maryam, Nikolaou Nikolaos, Parajes Silvia, Krone Nils P, Valsamakis George, Mastorakos George, Hughes Beverly, Taylor Angela, Bujalska Iwona J, Gathercole Laura L, Tomlinson Jeremy W

Abstract excerpt

Glucocorticoids and androgens have both been implicated in the pathogenesis of nonalcoholic fatty liver disease (NAFLD); androgen deficiency in males, androgen excess in females, and glucocorticoid excess in both sexes are associated with NAFLD. Glucocorticoid and androgen action are regulated at a prereceptor level by the enzyme 5α-reductase type 2 (SRD5A2), which inactivates glucocorticoids to their...

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Identifiers

PMID: 25974403
DOI: 10.1210/en.2015-1149
PMCID: PMC4511138

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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