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Article

Genetic variation in aldo-keto reductase 1D1 (AKR1D1) affects the expression and activity of multiple cytochrome P450s.

Drug metabolism and disposition: the biological fate of chemicals - 1 Aug 2013

Chaudhry Amarjit S, Thirumaran Ranjit K, Yasuda Kazuto, Yang Xia, Fan Yiping, Strom Stephen C, Schuetz Erin G

Abstract excerpt

Human liver gene regulatory (Bayesian) network analysis was previously used to identify a cytochrome P450 (P450) gene subnetwork with Aldo-keto reductase 1D1 (AKR1D1) as a key regulatory driver of this subnetwork. This study assessed the biologic importance of AKR1D1 [a key enzyme in the synthesis of bile acids, ligand activators of farnesoid X receptor (FXR), pregnane X receptor (PXR), and constitutive...

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Identifiers

PMID: 23704699
DOI: 10.1124/dmd.113.051672
PMCID: PMC4162005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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