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Article

Role of aldo-keto reductase family 1 (AKR1) enzymes in human steroid metabolism.

Steroids - 1 Jan 2014

Rižner Tea Lanišnik, Penning Trevor M

Abstract excerpt

Human aldo-keto reductases AKR1C1-AKR1C4 and AKR1D1 play essential roles in the metabolism of all steroid hormones, the biosynthesis of neurosteroids and bile acids, the metabolism of conjugated steroids, and synthetic therapeutic steroids. These enzymes catalyze NADPH dependent reductions at the C3, C5, C17 and C20 positions on the steroid nucleus and side-chain. AKR1C1-AKR1C4 act as 3-keto, 17-keto and...

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Identifiers

PMID: 24189185
DOI: 10.1016/j.steroids.2013.10.012
PMCID: PMC3870468

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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